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Related Experiment Videos

An electrodiagnostic study in chronic alcoholic subjects.

K Shankar1, F P Maloney, C Thompson

  • 1John L. McClellan Memorial Veterans' Hospital, Little Rock, AR 72205.

Archives of Physical Medicine and Rehabilitation
|November 1, 1987
PubMed
Summary

Electrodiagnostic tests reveal significant nerve conduction differences in alcoholic individuals. Specific ulnar and sural nerve tests effectively identify chronic alcoholism, correlating with drinking duration.

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Area of Science:

  • Neurology
  • Clinical Neurophysiology

Background:

  • Alcoholism is a prevalent condition with known neurological complications.
  • Peripheral neuropathy is a common manifestation of chronic alcohol abuse.

Purpose of the Study:

  • To investigate if electrodiagnostic nerve conduction parameters can differentiate between alcoholic subjects and healthy controls.
  • To identify which specific nerve conduction parameters are most sensitive to alcohol-induced nerve damage.

Main Methods:

  • Electrodiagnostic tests including nerve conduction studies (NCS) and H-reflex were performed on 16 alcoholic subjects and 15 age-matched controls.
  • Stepwise discriminant analysis was employed to determine the most effective combination of parameters for subject classification.

Main Results:

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  • Significant differences in median, ulnar, sural, and peroneal nerve conduction parameters were observed between alcoholic subjects and controls.
  • A combination of ulnar and sural sensory conduction velocity tests accurately identified 85% of chronic alcoholic subjects.
  • Tibial nerve H-reflex latencies were abnormal (absent or prolonged) in 63% of alcoholic subjects.
  • Ulnar sensory amplitude and velocity showed an inverse correlation with the duration of excessive alcohol consumption.

Conclusions:

  • Electrodiagnostic testing, particularly ulnar and sural nerve conduction studies, can effectively identify chronic alcoholics.
  • Nerve conduction abnormalities in alcoholism are widespread, affecting multiple peripheral nerves.
  • The duration of heavy alcohol intake is a significant factor contributing to the severity of nerve damage.