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Identification of erythropoietin receptors on fetal liver erythroid cells
A Tojo1, H Fukamachi, M Kasuga
1Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Biochemical and Biophysical Research Communications
|October 14, 1987
Abstract:
Erythropoietin (EPO) has a central role in the growth and development of erythroid cells. Using a biologically active radioiodinated derivative, EPO receptors were identified on fetal mouse liver cells mostly consisting of erythroid cells. 125I-EPO was cross-linked to two receptors forms with apparent molecular masses of 110 and 95 kilodaltons, respectively and both having similar affinity toward EPO.