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Ghrelin and cancer progression.

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Biochimica Et Biophysica Acta. Reviews on Cancer
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Ghrelin, a peptide hormone, influences cancer growth and spread. Its expression in various cancers suggests a role in disease progression and patient outcomes.

Keywords:
CancerGHSRGhrelinMetastasis

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Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Ghrelin is a 28-amino acid peptide hormone and the endogenous ligand for the growth hormone secretagogue receptor (GHSR).
  • Beyond its role in growth hormone release, ghrelin regulates energy balance, appetite, and gastrointestinal functions.
  • Ghrelin and GHSR are expressed in various tissues, indicating functions beyond their traditional physiological roles.

Purpose of the Study:

  • To review the biological functions of ghrelin in cancer progression, including metastasis and proliferation.
  • To investigate the expression of GHRL (ghrelin gene) and GHSR in pan-cancers using The Cancer Genome Atlas (TCGA) data.
  • To explore the clinical significance and impact of the ghrelin-GHSR axis on cancer patient outcomes.

Main Methods:

  • Literature review of ghrelin's functions in cancer.
  • Analysis of GHRL and GHSR gene expression data across various cancer types from TCGA.
  • Correlation analysis between ghrelin-GHSR axis expression and patient outcomes.

Main Results:

  • Ghrelin plays a significant role in promoting cancer cell proliferation and metastasis.
  • Aberrant expression of GHRL and GHSR is observed in multiple cancer types.
  • The expression levels of ghrelin and GHSR correlate with patient prognosis in certain cancers.

Conclusions:

  • The ghrelin-GHSR axis is implicated in cancer progression and represents a potential therapeutic target.
  • Understanding ghrelin's role in cancer can lead to improved diagnostic and prognostic strategies.
  • Further research is warranted to elucidate the precise mechanisms and clinical applications of targeting the ghrelin-GHSR pathway in oncology.