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Association between obesity-related biomarkers and cognitive and motor development in infants

Ana Cristina R Camargos1, Vanessa A Mendonça1, Katherine S C Oliveira2

  • 1Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil; Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Diamantina, Brazil.

Behavioural Brain Research
|February 28, 2017
PubMed

Insights

Obesity biomarkers like leptin and soluble tumor necrosis factor receptor 1 (sTNFR1) impact infant development. Higher sTNFR1 correlated with better cognitive and motor skills, while higher leptin levels were linked to reduced cognitive development in infants.

Area of Science:

  • Pediatric Endocrinology
  • Developmental Neuroscience
  • Biomarker Research

Background:

  • Obesity-related biomarkers may influence early childhood development.
  • Understanding these associations is crucial for identifying early developmental risks.

Purpose of the Study:

  • To investigate the relationship between obesity biomarkers and cognitive/motor development in infants aged 6-24 months.

Main Methods:

  • Cross-sectional study of 50 infants.
  • Measured plasma biomarkers including leptin, adiponectin, resistin, sTNFR1/2, BDNF, cortisol, and redox status.
  • Assessed cognitive and motor development using the Bayley-III test and analyzed associations with regression models.

Main Results:

  • Plasma leptin and sTNFR1 levels significantly associated with cognitive scores, explaining 37% of variability.
  • Plasma sTNFR1 levels significantly associated with motor scores, explaining 24% of variability.

Conclusions:

  • sTNFR1 levels correlate with enhanced cognitive and motor development in infants, independent of body weight.
  • Elevated leptin levels are associated with reduced cognitive development in this age group.
Abstract

Keywords:
AdipokinesBiomarkersChild developmentInfant obesity

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