Related Experiment Video
Updated: Mar 7, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Clinical considerations for optimal use of the polymyxins: A focus on agent selection and dosing
J M Pogue1, J K Ortwine2, K S Kaye3
1Department of Pharmacy Services, Sinai-Grace Hospital, Detroit Medical Center, USA; Wayne State University of Medicine, USA.
Abstract:
Polymyxins have remained the drug of choice for treatment due to carbapenem-resistant Gram-negative bacilli. Unfortunately, the utility of these agents has been limited by a lack of pharmacokinetic understanding, a high toxicity rate, and an extremely narrow therapeutic index. Significant advancements have been achieved in the understanding of the polymyxins over the past decade, and have led to the recognition of several differences between available intravenous formulations. The purpose of this review is to discuss the implications of these differences, assess comparative efficacy and safety of the polymyxins, and provide recommendations for polymyxin dosing and selection.
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacokinetics in Pediatric Patients: Drug Excretion
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Estimation of k and VD of Aminoglycosides
Modified-Release Drug Delivery Systems: Influencing Factors

