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Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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Decrease in regulatory T-cell function in chronic hepatitis C patients receiving pegylated-interferon plus ribavirin.

Kuo-Chih Tseng1, Yun-Che Ho2, Chi-Wei Tseng1

  • 1Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chia-Yi, Taiwan; School of Medicine, Tzuchi University, Hualien, Taiwan.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|February 28, 2017
PubMed
Summary

Combination therapy for chronic hepatitis C (CHC) reduces regulatory T-cell (Treg) immunosuppression. This Treg function was higher in patients achieving sustained virological response (SVR) post-treatment.

Keywords:
FunctionHepatitis CInhibitionInterferonRegulatory T-cells

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Area of Science:

  • Immunology
  • Hepatology
  • Pharmacology

Background:

  • Regulatory T-cells (Tregs) are crucial in chronic hepatitis C (CHC) pathogenesis.
  • Pegylated interferon-based combination therapy is standard for CHC in Asia.

Purpose of the Study:

  • To assess the frequency and function of Tregs in CHC patients undergoing combination therapy.
  • To correlate Treg function with treatment response.

Main Methods:

  • 30 CHC patients with elevated ALT receiving combination therapy were studied.
  • Treg immunosuppressive activity was measured via conventional T-cell proliferation inhibition.
  • Measurements were taken at baseline, 12 weeks, end of treatment, and 24-week follow-up.

Main Results:

  • Treg-mediated immunosuppression significantly decreased during and after therapy compared to baseline.
  • Immunosuppression levels were lower at 12 weeks, end of treatment, and follow-up.
  • Patients with sustained virological response (SVR) exhibited higher Treg immunosuppression post-treatment than non-SVR patients.

Conclusions:

  • Combination therapy lowers Treg-mediated immunosuppression in CHC patients.
  • Elevated Treg immunosuppression post-therapy correlates with a higher likelihood of SVR.