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The methylation state of the proviruses in avian sarcoma virus transformed chick and rat cells
N Roguel1, H Moskowitz, H Relevy
1Department of Molecular Genetics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Biochimica Et Biophysica Acta
|November 20, 1987
Abstract:
The endogenous viruses in the avian cells are not completely methylated, nor are the Schmidt-Ruppin RSV-D (SRD) proviruses in the infected cells completely unmethylated. Avian sarcoma proviruses integrated in rat transformed cloned cells are heavily methylated. In these cells, a region in the 3' end of the env gene is unmethylated in all the src-containing proviruses but not in the transformed defective (td) proviruses. A possible role for the hypomethylation of the 3' end of the env region is proposed.