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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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Synthesis and screening of peptide libraries with free C-termini
Yen-Chih Wang1, Mark D Distefano1
1Departments of Chemistry and Medicinal Chemistry, University of Minnesota, Minneapolis, MN, 55455, USA.
Abstract:
Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.
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