Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Complex pathogenetic therapy of experimental botulism].

G N Kryzhanovskiĭ, V V Morrison

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |November 1, 1987
    PubMed
    Summary

    Gutimine, an antihypoxic agent, demonstrated a protective effect against type C botulinum intoxication in mice and rats. Combined with 4-aminopyridine, its efficacy was enhanced, allowing for reduced dosages of both drugs.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Elimination of acute toxic action of streptomycin in experimental conditions].

    Antibiotiki·2014
    Same author

    Benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, a prolyl endopeptidase inhibitor, modulates depression-like behavior of rats in forced swimming test and activities of proline-specific peptidases in the brain structures.

    Bulletin of experimental biology and medicine·2013
    Same author

    Effect of imipramine and prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in the brain of rats with experimental anxious-depressive syndrome.

    Bulletin of experimental biology and medicine·2012
    Same author

    Activities of proline-specific peptidases in brain structures of rats with experimental anxiety-depressive state caused by administration of dipeptidyl peptidase IV inhibitor in the early postnatal period.

    Bulletin of experimental biology and medicine·2012
    Same author

    [Dysregulation of phospholipid metabolism of neuronal membranes in the nervous system pathology].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010
    Same author

    [Modeling of preclinical and early clinical stages of Parkinson's disease].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2010

    Area of Science:

    • Toxicology
    • Pharmacology
    • Neuroscience

    Context:

    • Botulinum intoxication poses a significant threat.
    • Understanding protective mechanisms is crucial for developing treatments.
    • Investigating novel therapeutic agents for intoxication is essential.

    Purpose:

    • To evaluate the protective effects of gutimine against type C botulinum intoxication.
    • To assess the synergistic effects of combining gutimine with 4-aminopyridine.
    • To determine if combined administration allows for reduced drug dosages.

    Summary:

    • Administration of the lethal dose 50 (LD50) of type C botulinum toxin to mice and rats was studied.
    • Gutimine (50-200 mg/kg) exhibited a protective effect against botulinum intoxication.
    • A combination of gutimine and 4-aminopyridine (1-5 mg/kg) showed a more pronounced protective effect, potentiating the therapeutic outcome and enabling dose reduction.

    Impact:

    • This study highlights the potential of gutimine as a therapeutic agent for botulinum intoxication.
    • The synergistic effect of gutimine and 4-aminopyridine offers a promising therapeutic strategy.
    • Reduced drug dosages in combination therapy could lead to improved safety profiles and reduced side effects.

    Related Experiment Videos