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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
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Life Expectancy in Pleural and Peritoneal Mesothelioma
Robert Shavelle1, Kate Vavra-Musser1, Jessica Lee1
1Life Expectancy Project, San Francisco, CA, USA.
Lung Cancer International
|February 28, 2017
Summary
Mesothelioma survival has seen only modest improvements, with life expectancies significantly reduced even for long-term survivors of pleural and peritoneal cancers. Prognosis remains poor despite some gains.
Area of Science:
- Oncology
- Epidemiology
- Cancer Research
Background:
- Mesothelioma, a rare cancer, historically presents with a poor prognosis.
- Significant research is needed to understand mesothelioma survival rates.
- Pleural and peritoneal mesothelioma require distinct survival analyses.
Purpose of the Study:
- To calculate life expectancies for mesothelioma patients at diagnosis and later.
- To assess survival improvements for mesothelioma over time.
- To identify factors influencing mesothelioma patient survival.
Main Methods:
- Analysis of 10,258 pleural and 1,229 peritoneal mesothelioma cases from the SEER database (1973-2011).
- Utilized the Cox proportional hazards regression model for survival analysis.
- Examined demographic, clinical, and treatment-related factors impacting survival.
Main Results:
- Survival rates improved modestly: 0.5% annually for pleural and 2% for peritoneal mesothelioma.
- Key survival predictors include age, sex, cancer stage, grade, histology, and treatment.
- Even 5-year survivors with optimal factors faced reduced life expectancies.
Conclusions:
- Mesothelioma significantly reduces life expectancy compared to the general population.
- Survival improvements over recent decades have been minimal.
- Prognosis for mesothelioma remains challenging, even with favorable patient characteristics and treatment.
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