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Updated: Mar 7, 2026
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in
Jan-Patrick Stellmann1, Hanife Cetin1, Kim Lea Young1
1Institut für Neuroimmunologie und Multiple Sklerose Universitätsklinikum Hamburg-Eppendorf Germany; Klinik und Poliklinik für Neurologie Universitätsklinikum Hamburg-Eppendorf Germany.
Background:
Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated.
Objective:
To investigate the association between focal cortical volume and thickness of retinal layers.
Methods:
Fifty-four patients (relapsing-remitting MS, mean age 40.5 years, mean disease duration 7.6 years, median EDSS 2) underwent OCT and MRI. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Patterns of association were determined with Yeo's functional network atlas and the Harvard-Oxford cortical atlas. We used GEE models with cortical volumes from the FreeSurfer parcellation to confirm VBM results. Post hoc, we analyzed the association between OCT, focal cortical volumes, and an extended neuropsychological assessment in a subgroup of 14 patients.
Results:
Macular retinal nerve fiber layer (mRNFL) and ganglion cell /inner plexiform layer (GCIPL) showed a robust association with mainly the insular cortex and the cingulate cortex. VBM findings were confirmed with FreeSurfer volumes. The post hoc analysis detected significant correlations between both OCT outcomes and cognition.
Conclusion:
Besides the primary visual system, OCT outcomes show a correlation pattern with cortical regions that are known to be important for cognitive performance, predominantly the insula in both hemispheres. Thus, OCT should be further investigated as a marker for neurodegeneration in MS.
