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Noradrenaline- and time-dependent changes in neocortical alpha 2- and beta 1-adrenoceptor binding in dorsal
D J Dooley1, G H Jones, T W Robbins
1Gödecke Research Institute, Freiburg, F.R.G.
Abstract:
A 6-hydroxydopamine-induced lesion of the dorsal noradrenergic bundle (DNB) in rats markedly decreased neocortical noradrenaline concentration (NNC) by 72-100% as measured 1, 3 and 13 months after the lesioning procedure. The concomitant assessment of neocortical alpha 2- and beta 1-adrenoceptor binding (NAAB and NBAB, respectively) usually indicated significant increases of 25-72% for these two variables. There were, however, cases of unchanged NAAB and NBAB which presumably reflected an incomplete DNB lesion and a consequent time-related, partial recovery of NNC. The results emphasize the potential for long-term sequelae of the DNB lesion, and the existence of a critical NNC threshold (approximately 10-30% of control NNC values) which modulates postsynaptic alpha 2- and beta 1-adrenoceptor density.