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Published on: November 29, 2016
Correlations between lncRNA-SOX2OT polymorphism and susceptibility to breast cancer in a Chinese population
Xiuwu Tang1, Yan Gao2,3, Linxiang Yu4
1Department of Gynecology & Obstetrics, the First Affiliated Hospital of Soochow University, Suzhou, China.
Aim:
We evaluated the effect of lncRNA SOX2OT expression and its SNP in tumorigenesis and development of breast cancer (BC) in a case-control study.
Methods:
A total of 1106 individuals, 505 newly diagnosed BC patients and 601 age-matched controls (±2 years) were testified. Real-time PCR was adopted for testing tissues' SOX2OT expression. Genotyping of rs9839776 were conducted by using SNaPshot assays.
Results:
SOX2OT were overexpressed in BC tissues (p < 0.001). SOX2OT SNP rs9839776 was strongly associated with the higher expression of SOX2OT and an increased risk of BC in Chinese women (odds ratio: 1.42; 95% CI: 1.06-1.90; p = 0.018).
Conclusion:
These results confirmed that BC was conspicuously associated with higher SOX2OT expression. SOX2OT SNP rs9839776 was significantly associated with the onset of BC possibly via influencing the expression of SOX2OT.
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