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Related Experiment Video

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Coral Reef Arks: An In Situ Mesocosm and Toolkit for Assembling Reef Communities
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[Are the Argonauts lost at sea?]

Bertrand Jordan1

  • 1UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS, Espace éthique méditerranéen, hôpital d'adultes la Timone, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France ; CoReBio PACA, case 901, parc scientifique de Luminy, 13288 Marseille Cedex 09, France.

Medecine Sciences : M/S
|February 28, 2017
PubMed
Summary

A new gene editing tool based on Argonaute nucleases showed promise but has proven difficult to replicate. Further research is needed to understand why this gene editing technology is not working as expected.

Area of Science:

  • Molecular Biology
  • Gene Editing Technologies
  • Biochemistry

Background:

  • A novel gene editing system utilizing Argonaute nucleases was reported in 2016.
  • This system was proposed to offer advantages over the established CRISPR-Cas9 technology.
  • Early reports suggested significant potential for this new gene editing approach.

Purpose of the Study:

  • To investigate the reproducibility and efficacy of the Argonaute-based gene editing system.
  • To identify potential reasons for the reported difficulties in replicating the technique.
  • To assess the validity of the initial findings concerning Argonaute nucleases in gene editing.

Main Methods:

  • Review of published literature and "grey literature" on Argonaute-based gene editing.

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  • Analysis of reported experimental outcomes from multiple independent research groups.
  • Comparison of experimental protocols and results to identify discrepancies.

    • Main Results:

    • Numerous attempts to utilize the Argonaute gene editing technique have been unsuccessful across multiple laboratories.
    • Several negative reports have been published, and anecdotal evidence of failure is widespread in the "grey literature".
    • The reasons for the lack of successful replication remain undetermined.

    Conclusions:

    • The widespread failure to reproduce the Argonaute gene editing technique raises significant concerns.
    • It is unclear whether the issues stem from an unknown critical experimental variable or from misinterpretation or fabrication of initial results.
    • Further investigation is crucial to resolve the discrepancies surrounding this gene editing technology.