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Related Experiment Video

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Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats
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Abnormal task driven neural oscillations in multiple sclerosis: A visuomotor MEG study.

Eleanor L Barratt1, Prejaas K Tewarie1, Margareta A Clarke2

  • 1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.

Human Brain Mapping
|February 28, 2017
PubMed
Summary
This summary is machine-generated.

Magnetoencephalography reveals altered brain activity in multiple sclerosis (MS) patients. Delays in motor cortex responses and reduced visual cortex activity correlate with impaired information processing speed in MS.

Keywords:
MEGmultiple sclerosisneuronal oscillationspost-movement beta reboundvisual gammavisuomotor abnormalities

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Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Biophysics

Background:

  • Multiple sclerosis (MS) is a neurological disease characterized by white matter myelin degradation, leading to varied symptoms like fatigue, vision, and movement problems.
  • Current MRI measures of demyelination poorly predict MS disease severity, necessitating functional brain assessments.
  • Magnetoencephalography (MEG) offers high temporal resolution to detect neural activity delays caused by demyelination.

Purpose of the Study:

  • To investigate visuomotor task-related brain activity changes in MS patients using MEG.
  • To correlate electrophysiological findings with clinical measures of disease severity, specifically information processing speed.

Main Methods:

  • A visuomotor task was employed to elicit event-related beta desynchronisation and post-movement beta rebound (PMBR) in the motor cortex, and gamma oscillations in the visual cortex.
  • MEG was used to record brain activity in MS patients and age/gender-matched healthy controls during the task.
  • The Symbol Digit Modalities Test (SDMT) was administered to assess information processing speed.

Main Results:

  • MS patients exhibited a significant delay in the time-to-peak of the post-movement beta rebound (PMBR).
  • This PMBR delay in MS patients significantly correlated with lower scores on the Symbol Digit Modalities Test (SDMT).
  • A significant reduction in the amplitude of visual gamma oscillations was observed in MS patients compared to controls.

Conclusions:

  • Electrophysiological imaging using MEG can reveal functional brain alterations in MS patients.
  • Altered motor cortex (PMBR) and visual cortex (gamma oscillations) activity are associated with MS.
  • These findings suggest MEG is a valuable tool for understanding visual disturbances and motor control deficits in MS.