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Related Concept Videos

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: Mar 7, 2026

In Vitro Evaluation of Oncogenic Transformation in Human Mammary Epithelial Cells
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In Vitro Evaluation of Oncogenic Transformation in Human Mammary Epithelial Cells

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Concepts in malignant transformation.

B D Bebington1

  • 1Wits Donald Gordon Medical Centre, Parktown, Johannesburg, South Africa.

South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
|February 28, 2017
PubMed
Summary

Malignant transformation may start with cell injury but progresses through self-determined epigenetic events. This theory integrates oncogenesis, cell biology, and evolutionary models for cancer research.

Area of Science:

  • Oncology
  • Cell Biology
  • Epigenetics

Background:

  • The exact biochemical mechanisms driving malignant transformation are not fully understood.
  • Current theories of oncogenesis offer fragmented explanations for cancer development.

Purpose of the Study:

  • To review existing oncogenesis theories.
  • To propose a unified schema for malignant transformation origins.
  • To explore the roles of cell injury and epigenetic events in neoplastic progression.

Main Methods:

  • Literature review of oncogenesis theories.
  • Synthesis of concepts into a proposed schema.
  • Consideration of evolutionary models and cell biology.

Main Results:

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  • A proposed schema for malignant transformation.
  • Hypothesis: Malignancy initiation by injury, promulgation via self-determined epigenetic events.
  • Integration of cell-programmed origin for neoplastic progression.

Conclusions:

  • The proposed schema offers a novel perspective on cancer origins.
  • Further experimental validation is needed to confirm the proposed mechanisms.
  • This framework aims to stimulate future research in oncogenesis.