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Updated: Mar 7, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
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Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

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The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

J Wesley Pike, Mark B Meyer, Seong-Min Lee

    The Journal of Clinical Investigation
    |February 28, 2017
    PubMed

    Insights

    The vitamin D receptor (VDR) regulates gene expression for essential biological functions, including mineral homeostasis. Understanding VDR actions is crucial for human health and disease research.

    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Genetics

    Background:

    • The vitamin D receptor (VDR) is the primary mediator of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in vertebrates.
    • VDR regulates gene expression within the nucleus of target cells, influencing diverse biological functions.
    • Key functions include maintaining mineral homeostasis and cell type-specific activities.

    Purpose of the Study:

    • To review recent advancements in understanding VDR.
    • To explore novel cellular sites of VDR action.
    • To elucidate the mechanisms of VDR-mediated gene regulation and its biological consequences.

    Main Methods:

    • This review synthesizes current research findings.
    • It integrates data on VDR cellular localization and function.
    • The review examines the molecular mechanisms of VDR action.

    Main Results:

    • New cellular sites of VDR action have been identified.
    • Detailed mechanisms of VDR-controlled gene expression are being uncovered.
    • The biological outcomes of VDR signaling are increasingly understood.

    Conclusions:

    • Significant progress has been made in defining VDR's role.
    • The translational impact of VDR on human health and disease is substantial.
    • Future research will further illuminate VDR biology and mechanisms.

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