Related Experiment Video
Updated: Mar 7, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.8K
Of generators, networks and migraine attacks
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Current Opinion in Neurology
|February 28, 2017
Summary
Migraine attacks may not originate from a single brain area. Recent studies suggest complex network interactions involving the hypothalamus and brainstem generate migraine pain.
Area of Science:
- Neuroscience
- Neurology
- Pain Research
Background:
- The origin of migraine attacks is a central topic in migraine pathophysiology.
- Debate continues regarding the specific brain and brainstem centers involved in migraine generation.
Purpose of the Study:
- To review current evidence on migraine attack origins.
- To synthesize findings from neuroimaging and clinical observations.
Main Methods:
- Review of recent neuroimaging studies focusing on the preictal stage of migraine.
- Analysis of functional connectivity changes in migraineurs.
Main Results:
- Neuroimaging suggests the hypothalamus plays a key role in the preictal stage.
- Altered resting-state functional connectivity in the dorsal pons and hypothalamus is observed in interictal migraineurs.
- Clinical presentation points to the hypothalamus and dopaminergic system, while neuroimaging implicates the dorsal pons.
Conclusions:
- A single migraine generator model is likely too simplistic.
- Migraine pain generation may result from spontaneous oscillations in complex neural networks.
- These oscillations may alter descending pain-modulating pathways via subcortical and brainstem areas.
Related Concept Videos
01:13Seizures: Classification
1.9K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.9K
01:21Generator Voltage Control
711
Generator voltage control is crucial for maintaining the stable operation of synchronous generators and wind turbines. In older models, a DC generator driven by the rotor delivers DC power to the rotor's field winding, and the power is transferred through slip rings and brushes. In the latest models, static or brushless exciters are used. Static exciters rectify AC power from the generator terminals and then transfer the DC power directly to the rotor. Brushless exciters, on the other hand, use...
711