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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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In Vitro Assay to Study Tumor-macrophage Interaction
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Tumor-associated macrophages: from basic research to clinical application.

Li Yang1,2, Yi Zhang3,4,5

  • 1Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Zhengzhou, 450052, Henan Province, China.

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Tumor-associated macrophages (TAMs) promote cancer progression by aiding tumor growth, metastasis, and angiogenesis. Understanding TAMs offers potential for cancer diagnosis, prognosis, and new therapies.

Keywords:
BiomarkerProtumoral activitiesTherapeutic targetTumor microenvironmentTumor-associated macrophages (TAMs)

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Area of Science:

  • Immunology
  • Oncology
  • Cancer Biology

Background:

  • Macrophages are immune cells found in tumor tissues.
  • Tumor-associated macrophages (TAMs) exhibit protumoral functions, contributing to cancer progression.
  • TAMs can be classically or alternatively activated, influencing their role in cancer.

Purpose of the Study:

  • To review the origin, polarization, and role of TAMs in human malignant tumors.
  • To explore the potential of TAMs as diagnostic and prognostic biomarkers for cancer.
  • To discuss TAMs as therapeutic targets in cancer treatment.

Main Methods:

  • Literature review of studies on TAMs in human malignant tumors.
  • Analysis of TAMs' contribution to tumor initiation, metastasis, angiogenesis, and immune evasion.
  • Examination of TAMs' utility in cancer diagnosis, prognosis, and therapy.

Main Results:

  • TAMs actively promote tumor cell initiation and metastasis.
  • TAMs suppress anti-tumor immune responses mediated by T cells.
  • TAMs stimulate tumor angiogenesis, driving cancer progression.

Conclusions:

  • TAMs are key players in cancer progression, influencing multiple aspects of tumor biology.
  • TAMs hold significant promise as biomarkers for cancer diagnosis and prognosis.
  • Targeting TAMs represents a viable strategy for novel cancer therapeutics.