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Related Experiment Video

Updated: Mar 7, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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[Cutaneous involvement in T-lymphoblastic lymphoma].

C Nascimbeni1, S Chantepie2, C Brugiere1

  • 1Service de dermatologie, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France; Université de Caen Normandie, 14000 Caen, France.

Annales De Dermatologie Et De Venereologie
|March 1, 2017
PubMed
Summary
This summary is machine-generated.

This case study presents a rare instance of T-cell lymphoblastic lymphoma (LBL-T) in an elderly male with unusual cutaneous and abdominal involvement. The patient responded well to CHOP chemotherapy, highlighting a novel presentation of this rare non-Hodgkin

Keywords:
Cutaneous involvementLocalisation cutanéeLymphome lymphoblastique TT-lymphoblastic lymphoma

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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Lymphoblastic lymphoma (LBL) is a rare non-Hodgkin's lymphoma (NHL).
  • Cutaneous involvement in LBL is infrequent, occurring in less than 20% of patients.
  • T-cell lymphoblastic lymphoma (LBL-T) is a subtype with distinct clinical and biological characteristics.

Observation:

  • A 66-year-old male presented with a progressively spreading scalp tumor, purplish skin macules/nodules, and a single spinal adenopathy.
  • Imaging revealed extensive retroperitoneal tissue infiltration and abdominal tumoral mass.
  • Skin biopsies confirmed LBL-T with cutaneous, bone, and retroperitoneal lymph node involvement, notably without a mediastinal mass.

Findings:

  • The patient's presentation was atypical for LBL-T, particularly given his age and the specific cutaneous and abdominal tumor syndrome.
  • Unlike typical cases in younger patients with widespread lesions and mediastinal mass, this elderly patient had a solitary adenopathy.
  • Treatment with four cycles of CHOP chemotherapy led to regression of cutaneous lesions and abdominal mass, with normalization of renal function.

Implications:

  • This case expands the known spectrum of clinical presentations for cutaneous LBL-T.
  • The findings suggest that LBL-T can occur in elderly individuals with unique extranodal manifestations.
  • Successful treatment with CHOP highlights its efficacy even in atypical and elderly patient presentations of LBL-T.