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Autophagy as a potential target for sarcoma treatment
Li Min1, Edwin Choy2, Raphael E Pollock3
1Sarcoma Biology Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Jackson 1115, Boston, MA 02114, USA.; Department of Orthopedics, West China Hospital, Sichuan University, 37 Guoxue Road, Chengdu, Sichuan 610041, China.
Biochimica Et Biophysica Acta. Reviews on Cancer
|March 1, 2017
Summary
Autophagy, a cellular process, is crucial for sarcoma cell survival and resistance to therapy. Targeting autophagy presents a promising new strategy for treating various sarcomas.
Area of Science:
- Cellular Biology
- Oncology
- Biochemistry
Background:
- Autophagy is a fundamental cellular process involved in maintaining homeostasis.
- Recent studies highlight autophagy's significant role in sarcoma development and progression.
- Autophagy influences sarcoma cell growth, proliferation, and survival under stress and therapy.
Purpose of the Study:
- To review the current understanding of autophagy's role in sarcoma.
- To explore the potential of targeting autophagy for sarcoma treatment.
- To discuss autophagy co-regulators as potential diagnostic and prognostic biomarkers.
Main Methods:
- Literature review of studies on autophagy in sarcoma.
- Analysis of research on autophagy's impact on sarcoma cell behavior.
- Investigation of autophagy-related biomarkers in sarcoma diagnosis and prognosis.
Main Results:
- Autophagy plays a critical role in sarcoma cell proliferation and survival.
- Autophagy contributes to sarcoma's resistance to various therapeutic interventions.
- Autophagy co-regulators show potential as sarcoma biomarkers.
Conclusions:
- Autophagy is a key factor in sarcoma pathogenesis and therapeutic resistance.
- Targeting the autophagic pathway offers a novel therapeutic avenue for sarcoma.
- Autophagy-related biomarkers may aid in sarcoma diagnosis and prognosis.
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