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Updated: Jan 19, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Collapsing glomerulopathy in systemic lupus erythematosus.

Kerolos Abadeer¹, Ali A Alsaad², Xochiquetzal J Geiger³

¹Department of Nephrology and Hypertension, Mayo Clinic Florida, Jacksonville, Florida, USA.

BMJ Case Reports

|March 1, 2017

Summary

Collapsing glomerulopathy (CG) is a rare kidney disease. Mycophenolate may prevent CG development, as seen in a lupus patient who relapsed after stopping treatment.

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Published on: November 1, 2015

Area of Science:

Nephrology
Immunology
Internal Medicine

Background:

Collapsing glomerulopathy (CG) is a severe kidney disease often leading to end-stage renal disease.
CG can be associated with various systemic disorders, including autoimmune conditions.

Observation:

A patient with systemic lupus erythematosus developed biopsy-proven CG with acute kidney injury.
The CG onset coincided with the abrupt discontinuation of mycophenolate mofetil treatment.

Findings:

The patient showed a significant response to treatment with mycophenolate mofetil and prednisone.
This case suggests a potential protective role for mycophenolate in preventing or managing CG.

Implications:

Mycophenolate mofetil may be crucial in the prevention and management of collapsing glomerulopathy, particularly in lupus patients.
Further research is warranted to elucidate the precise mechanisms by which mycophenolate influences CG pathogenesis.