Duodenal variceal bleed: an unusual cause of upper gastrointestinal bleed and a difficult diagnosis to make
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Updated: Mar 7, 2026

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
Published on: August 1, 2025
Shradha Bhagani1, Conchubhair Winters1, Sulleman Moreea1
1Department of Gastroenterology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
Abstract:
We present a case of recurrent upper gastrointestinal (GI) bleeding in a man aged 57 years with primary biliary cholangitis who was ultimately diagnosed with an isolated duodenal variceal bleed, which was successfully treated with histoacryl glue injection. Duodenal varices are an uncommon presentation of portal hypertension and can result in significant GI bleeding with a high mortality. Diagnosis can be difficult and therapeutic options limited. Endoscopic variceal sclerotherapy with histoacryl glue provides an effective treatment, though endoscopists need to remain aware of and vigilant for the serious complications of this treatment option.
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