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Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized

Mohsin Qadeer1, Muhammad Waqas1, Muhammad Jawad Rashid2

  • 1The Aga Khan University Hospital, Karachi, Pakistan.

Asian Spine Journal
|March 1, 2017
PubMed
Summary
This summary is machine-generated.

Pregabalin and gabapentin show equivalent pain relief after lumbar microdiscectomy. Consider other factors like cost and side effects when prescribing these analgesics.

Keywords:
GabapentinIntervertebral disc displacementLumbar vertebraePostoperative painPregabalin

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Area of Science:

  • Anesthesiology and Pain Management
  • Neurosurgery
  • Pharmacology

Background:

  • Pregabalin offers potential pharmacokinetic and analgesic advantages over gabapentin.
  • Establishing analgesic efficacy in the perioperative period after lumbar spine surgery is crucial.

Purpose of the Study:

  • To compare the efficacy of pregabalin and gabapentin in managing postoperative pain following single-level lumbar microdiscectomy.
  • To evaluate pain scores using the Visual Analog Scale (VAS) in patients undergoing lumbar disc surgery.

Main Methods:

  • A randomized controlled trial involving 78 patients undergoing lumbar microdiscectomy.
  • Patients received either gabapentin or pregabalin one week pre-surgery.
  • Postoperative pain was assessed using the VAS at 24 hours and one week.

Main Results:

  • Both pregabalin and gabapentin demonstrated comparable pain relief at 24 hours and one week post-surgery (p>0.05).
  • No patients required additional analgesia in either treatment group.
  • Adjusted analysis showed no statistically significant difference in VAS scores between the groups.

Conclusions:

  • Pregabalin is therapeutically equivalent to gabapentin for postoperative pain management after lumbar microdiscectomy at the studied doses.
  • Factors beyond efficacy, including dosage, cost, pharmacokinetics, and side effect profiles, should guide clinical prescribing decisions.