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Related Experiment Video

Updated: Mar 7, 2026

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Is frailty a relevant concept in SLE?

Patricia P Katz1, James Andrews2, Jinoos Yazdany1

  • 1University of California San Francisco , San Francisco, California , USA.

Lupus Science & Medicine
|March 1, 2017
PubMed
Summary
This summary is machine-generated.

Frailty is common in women with lupus and linked to worse physical and cognitive function and higher mortality. Early identification of frailty in lupus patients is crucial for better health outcomes.

Keywords:
Outcomes researchQuality of LIfeSystemic Lupus Erythematosus

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Area of Science:

  • Rheumatology
  • Geriatrics
  • Public Health

Background:

  • Frailty is a significant predictor of adverse health outcomes in geriatric populations.
  • The prevalence and impact of frailty in systemic lupus erythematosus (SLE) remain under-examined, despite overlapping phenotypic characteristics.

Purpose of the Study:

  • To investigate the prevalence of frailty in women with SLE.
  • To examine the association between frailty and physical functioning, cognitive function, and mortality in this cohort.

Main Methods:

  • A cohort of 152 women with lupus was assessed for frailty using Fried's phenotype criteria (weight loss, exhaustion, weakness, slow gait, low activity).
  • Physical and cognitive functions were evaluated using standardized scales and tests.
  • Mortality data were collected up to December 2015, with statistical analyses controlling for relevant covariates.

Main Results:

  • 20% of women with lupus were classified as frail and 50% as prefrail, a higher prevalence than in non-lupus older adults.
  • Frail women exhibited significantly poorer physical functioning, higher rates of cognitive impairment, and greater functional decline.
  • Mortality rates were substantially higher in the frail group (19.4%) compared to prefrail (3.9%) and robust (2.3%) groups, with an elevated, though not statistically significant, adjusted odds ratio for death.

Conclusions:

  • Frailty is prevalent in women with lupus and is associated with adverse physical and cognitive health outcomes.
  • Frailty in lupus patients predicts functional decline and increased mortality risk.
  • These findings highlight the importance of assessing frailty in lupus management to improve patient prognosis.