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Related Experiment Videos

Endogenous cardiac glycosidelike compounds.

R A Kelly1

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.

Hypertension (Dallas, Tex. : 1979)
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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Researchers have long sought endogenous inhibitors of the sodium pump (Na+,K+-adenosine triphosphatase [ATPase]) that bind to its cardiac glycoside site. Despite advances, conclusive proof for these specific endogenous ligands remains elusive.

Area of Science:

  • Biochemistry
  • Physiology
  • Cardiovascular Research

Background:

  • The existence of endogenous inhibitors for the sodium pump (Na+,K+-adenosine triphosphatase [ATPase]) has been debated.
  • Many compounds modulate Na+,K+-ATPase activity indirectly, but direct binding to the cardiac glycoside site is unproven.

Purpose of the Study:

  • To review the historical search for endogenous Na+,K+-ATPase inhibitors.
  • To discuss recent progress in identifying potential ligands for the cardiac glycoside binding site.

Main Methods:

  • Literature review of studies investigating endogenous modulators of Na+,K+-ATPase.
  • Analysis of compounds affecting sodium pump activity in relation to hypertension and renal failure.

Main Results:

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  • Numerous hormones and ions indirectly affect Na+,K+-ATPase activity.
  • No endogenous compound has been definitively shown to bind the cardiac glycoside site on Na+,K+-ATPase.
  • Progress has been made in characterizing compounds that could affect Na+,K+-ATPase activity.

Conclusions:

  • The search for endogenous ligands for the cardiac glycoside binding site on Na+,K+-ATPase continues.
  • Definitive proof for such endogenous inhibitors remains elusive despite ongoing research.