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Related Experiment Video

Updated: Mar 7, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
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Neural pathways subserving face-based mentalizing.

Yordanka Nikolova Yordanova1,2, Hugues Duffau3,2,4, Guillaume Herbet5,6,7

  • 1Department of Neurosurgery, 'Percy' Military Hospital, 101 Av Henri Barbusse, 92140, Clamart, France.

Brain Structure & Function
|March 1, 2017
PubMed
Summary
This summary is machine-generated.

This study mapped brain pathways for mentalizing using direct electrical stimulation in patients with gliomas. Findings reveal the inferior fronto-occipital fasciculus and superior longitudinal fasciculus are crucial for inferring mental states from faces.

Keywords:
Arcuate fasciculusBrain mappingInferior fronto-occipital fasciculusMentalizingSocial cognition

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neurosurgery

Background:

  • The neural networks for mentalizing are increasingly understood, particularly cortical regions.
  • However, the white matter pathways connecting these regions remain largely unelucidated.

Purpose of the Study:

  • To identify critical white matter pathways involved in face-based mentalizing.
  • To investigate the role of specific fasciculi in inferring mental states from facial cues.

Main Methods:

  • Direct electrical stimulation (DES) mapping was performed in 27 patients with right-sided diffuse low-grade gliomas during awake surgery.
  • Cortical and subcortical sites were stimulated to assess effects on face-based mentalizing.
  • Disconnectome analyses were used to map affected white matter tracts.

Main Results:

  • Cortical sites in the inferior frontal gyrus, dorsolateral prefrontal cortex, and superior temporal gyrus were confirmed.
  • Key subcortical sites were identified along the inferior fronto-occipital fasciculus (IFOF) and within white matter supplying the dorsolateral prefrontal cortex.
  • Disconnectome analyses implicated the IFOF and the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF).

Conclusions:

  • Functional integrity of the IFOF and SLF is essential for accurate mental state inference from faces.
  • This study elucidates the white matter architecture supporting the mentalizing network.
  • Findings highlight the importance of preserving these tracts during neurosurgery.