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Related Experiment Videos

Peripheral nerve involvement in cutaneous leishmaniasis (Old World).

R Kubba1, A M el-Hassan, Y Al-Gindan

  • 1National Leishmaniasis Research Project (SANCST), King Faisal University, Dammam, Saudi Arabia.

International Journal of Dermatology
|October 1, 1987
PubMed
Summary

Cutaneous leishmaniasis caused by Leishmania major can affect nerves, with 5% of skin biopsies showing nerve changes like inflammation and destruction. Some patients also experienced diminished skin sensation due to these nerve alterations.

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Area of Science:

  • Dermatology
  • Neurology
  • Infectious Diseases

Background:

  • Cutaneous leishmaniasis (CL) is a parasitic disease caused by Leishmania species.
  • Leishmania major is a common causative agent of CL, particularly in certain regions.
  • The pathological effects of CL on skin structures are well-documented, but nerve involvement requires further investigation.

Observation:

  • A review of 288 skin biopsy specimens from CL lesions caused by Leishmania major was conducted.
  • Nerve changes were identified in 14 specimens (5%).
  • These changes included perineural inflammatory cell infiltrate, neuritis, nerve destruction, and intraneural amastigotes.

Findings:

  • Perineural inflammation was observed in 10 patients.
  • Neuritis with inflammatory cell invasion of nerves occurred in 4 patients, with one case showing granulomatous inflammation and nerve destruction.

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  • Amastigotes were found within nerves in 2 patients.
  • Sensory testing revealed diminished sensation in 2 out of 50 CL patients.

    • Implications:

    • Leishmania major infection can directly impact peripheral nerves, leading to significant histopathological changes.
    • Nerve involvement in CL may contribute to sensory disturbances experienced by patients.
    • Understanding these neuropathological aspects is crucial for comprehensive patient management and treatment strategies for cutaneous leishmaniasis.