Related Experiment Videos
Binding of C-terminal segments of neuropeptide Y to chicken brain
M O Perlman1, J M Perlman, M L Adamo
1Department of Chemistry, University of Houston, Texas.
International Journal of Peptide and Protein Research
|August 1, 1987
Abstract:
The C-terminal pentapeptide amide segment of neuropeptide Y (NPY) binds specifically to chicken brain membrane preparations. The contribution of each residue of the C-terminus to this binding has been investigated through the synthesis and evaluation of a series of pentapeptide analogs. The binding of these molecules is strongly dependent on the presence of certain functional groups, in particular the guanidinium group of Arg-35 and the C-terminal aromatic amide function. The significance of these results for the binding to chicken brain tissue of NPY, pancreatic polypeptide and other potentially related neuropeptides is discussed.