Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

1.1K
A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

4.3K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.3K
Increased Body Temperature01:25

Increased Body Temperature

7.6K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
7.6K
Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

9.8K
As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
9.8K
Methods of reducing fever01:22

Methods of reducing fever

1.5K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sanjay Pandey, MBBS, MD, DNB, DM, FIAN, and Aasef Shaikh, MD, PhD.

Seminars in neurology·2026
Same author

A Modified Delphi Consensus-Based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination.

Critical care medicine·2026
Same author

Integrating Brain Imaging Volumetrics and Quantitative Pupillometry for Predicting Neurologic Deterioration after Large Hemispheric Stroke.

Neurocritical care·2026
Same author

Connectome disruptions after hypoxic-ischaemic injury associate with consciousness disorder severity.

Brain communications·2026
Same author

Joseph Schindler, MD, and Charles Matouk, MD.

Seminars in neurology·2026
Same author

Quantified Brain Atrophy and Risk of Severe Mass Effect in Acute Ischemic Stroke.

medRxiv : the preprint server for health sciences·2026
Same journal

Visual Impairment and Driving in Older Adults: A Narrative Review.

Current treatment options in neurology·2026
Same journal

Non-Cognitive Symptoms in Alzheimer's Disease and Their Likely Impact on Patient Outcomes. A Scoping Review.

Current treatment options in neurology·2026
Same journal

Update on the Treatment of Autonomic Disorders.

Current treatment options in neurology·2025
Same journal

Primary Progressive Aphasia Treatment: Current Treatment Options in Neurology Article Topic: Management of Primary Progressive Aphasia.

Current treatment options in neurology·2025
Same journal

Emerging Principles for Treating Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD).

Current treatment options in neurology·2025
Same journal

Diagnosis and Management of Progressive Corticobasal Syndrome.

Current treatment options in neurology·2025
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K

Normothermia and Stroke.

Jonathan Marehbian1, David M Greer2

  • 1Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Yale University School of Medicine, 15 York Street, Building LLCI, 10th Floor, Suite 1003, New Haven, CT, 06520, USA. jonathan.marehbian@yale.edu.

Current Treatment Options in Neurology
|March 1, 2017
PubMed
Summary
This summary is machine-generated.

Targeted temperature management (TTM) shows neuroprotective benefits, but optimal protocols for timing, duration, and rewarming remain unclear. Aggressive fever control is a safe alternative if TTM is not feasible.

Keywords:
Acute ischemic strokeFeverHypothermiaIntracerebral hemorrhageNormothermiaStrokeSubarachnoid hemorrhage

More Related Videos

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

25.2K
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.5K

Related Experiment Videos

Last Updated: Mar 7, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.3K
Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

25.2K
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.5K

Area of Science:

  • Neurology
  • Critical Care Medicine
  • Therapeutic Hypothermia

Background:

  • Decades of research focus on fever's adverse neurologic effects and hypothermia's benefits.
  • Existing studies (RCTs, case-controlled) lack the power to definitively compare targeted temperature modulation (TTM) with hypothermia alone.
  • Key TTM parameters like initiation timing, duration, rewarming speed, and depth require further clarification.

Purpose of the Study:

  • To review the current understanding of targeted temperature management (TTM) and its implications for neurologic outcomes.
  • To highlight the gaps in knowledge regarding optimal TTM protocols.
  • To discuss the benefits and challenges of hypothermia and normothermia in neuroprotection.

Main Methods:

  • Literature review of studies on fever, hypothermia, and TTM in neurologic outcomes.
  • Analysis of findings from randomized trials, safety/feasibility studies, and case-controlled research.
  • Discussion of clinical experience and expert opinion on TTM implementation.

Main Results:

  • Hypothermia and near-normothermia (36°C) demonstrate neuroprotective value, particularly post-cardiac arrest.
  • Increased cooling depth correlates with shivering, necessitating aggressive pharmacologic management.
  • Normothermia offers advantages in medication clearance and neuroprognostication, with potentially less care complexity than moderate hypothermia.

Conclusions:

  • Optimal TTM protocols (timing, duration, rewarming) require further investigation via large, multicenter RCTs.
  • TTM should be implemented in experienced ICUs under protocol, with vigilant shivering management and acceptance of complications.
  • Aggressive fever control using non-invasive and pharmacologic methods is a safe alternative when TTM is not considered.