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Updated: Mar 7, 2026
Measurement of Spatial Stability in Precision Grip
Published on: June 4, 2020
Circulating CD34-Positive Cells Are Associated with Handgrip Strength in Japanese Older Men: The Nagasaki Islands
H Yamanashi1, Y Shimizu, J Koyamatsu
1Hirotomo Yamanashi, MD, Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Goto, Nagasaki 853-8691, Japan, E-mail: yamanashi@nagasaki-u.ac.jp, Tel: +81-959-74-2673, Fax: +81-959-74-2635.
Background:
Handgrip strength is a simple measurement of overall muscular strength and is used to detect sarcopenia. It also predicts adverse events in later life. Many mechanisms of sarcopenia development have been reported. A hypertensive status impairs endothelial dysfunction, which might deteriorate skeletal muscle if vascular angiogenesis is not maintained.
Objectives:
This study investigated muscle strength and circulating CD34-positive cells as a marker of vascular angiogenesis.
Design:
Cross-sectional study.
Participants:
262 male Japanese community dwellers aged 60 to 69 years.
Measurements:
The participants' handgrip strength, medical history, and blood samples were taken. We stratified the participants by hypertensive status to investigate the association between handgrip strength and circulating CD34-positive cells according to hypertensive status. Pearson correlation and linear regression analyses were used.
Results:
In the Pearson correlation analysis, handgrip strength and the logarithm of circulating CD34-positive cells were significantly associated in hypertensive participants (r=0.22, p=0.021), but not in non-hypertensive participants (r=-0.01, p=0.943). This relationship was only significant in hypertensive participants (ß=1.94, p=0.021) in the simple linear regression analysis, and it remained significant after adjusting for classic cardiovascular risk factors (ß=1.92, p=0.020). The relationship was not significant in non-hypertensive participants (ß=-0.09, p=0.903).
Conclusions:
We found a positive association between handgrip strength and circulating CD34-positive cells in hypertensive men. Vascular maintenance attributed by circulating CD34-positive cells is thought to be a background mechanism of this association after hypertension-induced vascular injury in skeletal muscle.
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