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Related Experiment Video

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Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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Lymphedema evaluation using noninvasive 3T MR lymphangiography.

Rachelle Crescenzi1, Paula M C Donahue2,3, Katherine G Hartley1

  • 1Radiology and Radiological Science, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Journal of Magnetic Resonance Imaging : JMRI
|March 1, 2017
PubMed
Summary

This study introduces a new 3.0T lymphangiography MRI sequence to detect lymphedema. The noninvasive method successfully identified lymphatic fluid stasis in patients, offering a faster alternative to contrast agents.

Keywords:
MRIbreast cancerlymphangiographylymphedemamanual lymphatic drainageturbo spin echo

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Area of Science:

  • Radiology
  • Medical Imaging
  • Lymphatic System Research

Background:

  • Lymphedema, often a consequence of cancer treatment, involves lymphatic fluid accumulation.
  • Current diagnostic methods for lymphedema can be invasive or time-consuming.
  • Exploiting the unique properties of lymphatic fluid at 3.0T MRI offers a potential for noninvasive imaging.

Purpose of the Study:

  • To develop a noninvasive 3.0T lymphangiography MRI sequence.
  • To evaluate the sequence's effectiveness in detecting lymphedema.
  • To leverage long relaxation times and low flow velocity of lymphatic fluid for imaging.

Main Methods:

  • A 3.0T turbo-spin-echo (TSE) pulse train with extended echo time was developed.
  • The sequence was tested on healthy adults and patients with breast cancer treatment-related lymphedema (BCRL).
  • Measurements included lymphatic vessel cross-sectional area and signal-to-noise ratio (SNR) before and after manual lymphatic drainage (MLD).

Main Results:

  • Affected limbs in BCRL patients showed significantly larger lymphatic vessel cross-sectional areas compared to contralateral sides and controls.
  • Lymphatic vessel areas decreased significantly in the torso after MLD therapy.
  • The developed sequence detected upper extremity lymph stasis in approximately 10 minutes without contrast agents.

Conclusions:

  • A novel 3.0T lymphangiography sequence effectively detects upper extremity lymph stasis.
  • This noninvasive MRI technique provides a rapid and contrast-agent-free method for lymphedema evaluation.
  • The sequence shows promise for clinical application in diagnosing and monitoring lymphedema.