AMH levels in girls with various pubertal problems.

Area of Science:

• Pediatric endocrinology
• Reproductive endocrinology
• Gynecology

Background:

• Anti-Müllerian hormone (AMH) is produced by granulosa cells in early-stage ovarian follicles.
• Serum AMH levels exhibit significant individual variability in healthy girls.
• Understanding AMH dynamics is crucial for evaluating pubertal development disorders.

Purpose of the Study:

• To investigate and compare serum AMH levels in girls diagnosed with premature thelarche (PT) and central precocious puberty (CPP).
• To assess the relationship between AMH levels and other hormonal markers in these conditions.

Main Methods:

• A comparative study involving three groups of girls: CPP (n=21), PT (n=24), and a prepubertal control group (n=22).
• Serum AMH levels were measured and compared across the groups.
• Correlations between AMH and hormones like LH, testosterone, DHEAS, and SHBG, as well as anthropometric measures (HSDS, BMI SDS), were analyzed.

Main Results:

• Serum AMH levels were significantly elevated in the PT group compared to the prepubertal control group.
• AMH levels in the CPP group were comparable to both the PT and control groups.
• In the PT group, AMH showed negative correlations with LH, free testosterone, and DHEAS. In the CPP group, AMH correlated negatively with HSDS and BMI SDS, and positively with SHBG. The control group showed a positive correlation between AMH and SHBG.

Conclusions:

• Girls with premature thelarche exhibit higher serum AMH levels than their prepubertal counterparts.
• Serum AMH levels do not significantly differ between girls with central precocious puberty, premature thelarche, and healthy prepubertal controls.