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Anti-inflammatory coumarins from Paramignya trimera.

Hoang Le Tuan Anh1, Dong-Cheol Kim2, Wonmin Ko2

  • 1a Institute of Marine Biochemistry , Vietnam Academy of Science and Technology (VAST) , Cau Giay , Hanoi , Vietnam.

Pharmaceutical Biology
|March 1, 2017
PubMed
Summary

Paramignya trimera stems yielded seven coumarins. Ostruthin and ninhvanin demonstrated significant anti-neuroinflammatory effects by inhibiting nitric oxide and prostaglandin E2 production, and suppressing iNOS and COX-2 expression.

Keywords:
6-(2-hydroxyethyl)-2,2-dimethyl-2H-1-benzopyran6-(6′,7′-dihydroxy-3′,7′-dimethylocta-2′-enyl)-7-hydroxycoumarin6-(7-hydroperoxy-3,7-dimethylocta-2,5-dienyl)-7-hydroxycoumarin8-geranyl-7-hydroxycoumarinBV2 microgliaRutaceaeluvangetinninhvaninostruthin

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Neuroscience

Background:

  • Paramignya trimera (Rutaceae) is traditionally used for liver diseases and cancer.
  • The anti-inflammatory properties of P. trimera and its constituents remain largely uninvestigated.

Purpose of the Study:

  • To isolate and identify chemical constituents from P. trimera stems.
  • To evaluate the anti-inflammatory effects of these isolated compounds.

Main Methods:

  • Isolation and structural elucidation of coumarins from P. trimera stems.
  • Assessment of nitric oxide (NO) and prostaglandin E2 (PGE2) inhibition in LPS-stimulated BV2 cells.
  • Evaluation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression via Western blot analysis.

Main Results:

  • Seven coumarins were isolated: ostruthin (1), ninhvanin (2), 8-geranyl-7-hydroxycoumarin (3), compound 4, compound 5, compound 6, and luvangetin (7).
  • Compounds 1-4 and 7 significantly inhibited NO and PGE2 production in LPS-stimulated BV2 cells.
  • Ostruthin (1) and ninhvanin (2) effectively suppressed LPS-induced iNOS and COX-2 protein expression.

Conclusions:

  • This study provides scientific validation for the traditional use of P. trimera in managing neuroinflammatory conditions.
  • Ostruthin and ninhvanin show potential as therapeutic agents for neuroinflammation and warrant further investigation.