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Published on: November 12, 2019
Historical and Clinical Experiences of Gene Therapy for Solid Cancers in China
Bo Li1, Ning Gao2,3, Zhuang Zhang4,5
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. li_yi@scu.edu.cn.
Abstract:
Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy.
Insights
Gene therapy offers a promising approach to treating diseases like cancer. This review details the history and development of gene therapy clinical trials in China, covering protocols and outcomes.
Area of Science:
- Oncology
- Genetics
- Medical Research
Background:
- Gene therapy, a promising medical treatment, has a nearly 27-year history since its first authorized study in 1989.
- Despite its potential, gene therapy adoption was slow globally until recently.
- China has been actively conducting gene therapy clinical trials since 1998, contributing significantly to medical research.
Purpose of the Study:
- To review the history of gene therapy in China.
- To provide comprehensive information on treatment protocols, administration cycles, dosage calculations, and therapeutic effect evaluations.
- To support the further development of gene therapy as a treatment strategy.
Main Methods:
- Historical review of gene therapy clinical trials in China.
- Analysis of treatment protocols and administration parameters.
- Evaluation of therapeutic effects and outcomes.
Main Results:
- Gene therapy research has flourished in China since 1998.
- Established protocols for gene therapy administration and dosage calculation exist.
- Therapeutic effects of gene therapy have been evaluated.
Conclusions:
- Gene therapy is a developing and promising treatment strategy for various diseases.
- China's contributions to gene therapy research are substantial.
- Further development of gene therapy can be informed by this review of Chinese clinical trials.
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