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Developing a Rat Model for Bipolar Disorder
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Pharmacological agents to reduce readmissions in bipolar disorder
Jonathan Rogers1, Matthew J Taylor1
1Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Journal of Psychopharmacology (Oxford, England)
|March 2, 2017
Summary
Several medications significantly reduce hospital admissions for bipolar disorder relapse. This network meta-analysis of 11 trials found lithium, valproate, carbamazepine, and olanzapine effective in preventing hospitalization.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Medicine
Background:
- Medications are crucial for preventing bipolar disorder relapse.
- Hospitalization rates are a key outcome but less studied for these treatments.
Purpose of the Study:
- To evaluate the effectiveness of pharmacological treatments in reducing hospital admissions for bipolar disorder.
- To synthesize evidence from randomized controlled trials using network meta-analysis.
Main Methods:
- Network meta-analysis combining data from 11 randomized controlled trials.
- Comparison of admission rates between various medications and placebo.
Main Results:
- Lithium, valproate, lithium/valproate combination, carbamazepine, and olanzapine showed significant reductions in hospital admission rates compared to placebo.
- Risk ratios (RR) ranged from 0.27 (olanzapine) to 0.50 (valproate/combination).
- The current evidence base is limited, resulting in broad confidence intervals.
Conclusions:
- Several pharmacological treatments are effective in reducing hospital admissions for individuals with bipolar disorder.
- Further research with larger datasets, including unpublished data, is needed for more precise estimates.
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