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Curcumin: Not So Spicy After All.

Amitabh Jha1, Prabhu P Mohapatra1, Salma A AlHarbi1

  • 1Department of Chemistry, Acadia University, Wolfville, NS B4P 2R6. Canada.

Mini Reviews in Medicinal Chemistry
|March 2, 2017
PubMed
Summary
This summary is machine-generated.

Curcumin shows medicinal promise but faces development hurdles due to poor pharmacokinetics. Recent studies explore synthetic analogs and methods to overcome these limitations for therapeutic applications.

Keywords:
AnticancerMichael acceptorantioxidantcurcumincurcumin analogsdiarylheptanoidsdiarylpentanoidsformulationsmechanism of actionpharmacokineticstopoisomerase IIα inhibitors.

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Natural Product Derivatives

Background:

  • Curcumin exhibits diverse medicinal properties with significant therapeutic potential.
  • Clinical application of curcumin is limited by its poor pharmacokinetic profile.
  • Recent research focuses on overcoming these pharmacokinetic challenges.

Purpose of the Study:

  • To review recent studies on curcumin and its analogs.
  • To present synthetic curcumin analogs and their properties.
  • To discuss methods developed to improve curcumin's pharmacokinetics.

Main Methods:

  • Literature review of recent studies on curcumin and its analogs.
  • Description of methods to enhance curcumin pharmacokinetics.
  • Presentation of biological and other properties of synthetic analogs.

Main Results:

  • Curcumin possesses broad medicinal properties but suffers from poor pharmacokinetics.
  • Synthetic curcumin analogs, including diarylheptanoids and diarylpentanoid monocarbonyl derivatives, show promising biological activities.
  • Novel methods have been developed to address the pharmacokinetic limitations of curcumin.

Conclusions:

  • Synthetic curcumin analogs offer a promising avenue for therapeutic development.
  • Addressing pharmacokinetic issues is crucial for realizing curcumin's clinical potential.
  • Further research into these analogs and delivery methods is warranted.