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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

334
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
334
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

294
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
294
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

306
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
306
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

771
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
771
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

283
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
283
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

294
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
294

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Related Experiment Video

Updated: Mar 7, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.5K

[Patient-oriented medicine in the elderly].

C C Sieber1,2

  • 1Klinik für Allgemeine Innere Medizin und Geriatrie, Krankenhaus Barmherzige Brüder Regensburg, Regensburg, Deutschland. cornel.sieber@fau.de.

Der Internist
|March 2, 2017
PubMed
Summary

Older adults often face multiple chronic conditions, requiring patient-centered care focused on maintaining function and independence rather than cure. Treatment goals for the elderly prioritize quality of life and independence over survival.

Keywords:
ComorbidityFrail elderlyGeriatricsPolypharmacyRehabilitation

Related Experiment Videos

Last Updated: Mar 7, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.5K

Area of Science:

  • Gerontology
  • Internal Medicine
  • Public Health

Background:

  • Aging is frequently associated with multimorbidity, involving chronic illnesses exacerbated by acute conditions.
  • Coexistence of physical and psychological diseases is common in older adults.
  • Multimorbidity often leads to polypharmacy in the elderly population.

Purpose of the Study:

  • To emphasize a shift from classical curative goals to patient-oriented care in older adults with multimorbidity.
  • To highlight the distinct therapeutic priorities for elderly patients, focusing on functionality and independence.
  • To underscore the importance of rehabilitative treatments and aligning care with patient-expressed goals.

Main Methods:

  • This study is a review and conceptual analysis of geriatric care principles.
  • It synthesizes current understanding of multimorbidity in aging populations.
  • No specific patient data or clinical trials were involved; it's based on established medical knowledge.

Main Results:

  • Classical curative approaches are often inappropriate for older adults with multimorbidity.
  • Patient-centered care, prioritizing functionality and independence, is crucial.
  • Rehabilitative interventions and consideration of patient- and caregiver-defined goals are essential.

Conclusions:

  • The management of multimorbidity in older adults necessitates a paradigm shift towards patient-oriented care.
  • Preservation of functionality and independence should supersede survival as the primary treatment endpoint.
  • Therapeutic strategies must be individualized, considering polypharmacy and the unique goals of elderly patients and their caregivers.