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Updated: Mar 7, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
14.0K
[Antihormonal therapy in prostate cancer : Side effects].
1Klinik für Urologie und Kinderurologie, Universität des Saarlandes, 66421, Homburg/Saar, Deutschland. carsten.ohlmann@uks.eu.
Der Urologe. Ausg. A
|March 2, 2017
Summary
Androgen deprivation therapy for prostate cancer can cause hidden side effects and resistance. Monitoring these issues and strategically using therapies like bipolar androgen therapy may restore treatment sensitivity.
Area of Science:
- Oncology
- Endocrinology
Background:
- Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer treatment.
- Common ADT drugs include abiraterone and enzalutamide.
- Subtle side effects like metabolic, cardiovascular, and psychological changes are often overlooked.
Purpose of the Study:
- To highlight the importance of monitoring occult side effects of ADT.
- To discuss mechanisms of ADT resistance, including splice variants.
- To explore strategies for overcoming ADT resistance.
Main Methods:
- Review of current ADT practices and their associated challenges.
- Analysis of molecular mechanisms underlying ADT resistance.
- Discussion of potential therapeutic interventions.
Main Results:
- ADT efficacy is often limited by primary and secondary resistance.
- Molecular mechanisms, such as androgen receptor splice variants, are key to resistance.
- These resistance mechanisms are often reversible.
Conclusions:
- Active monitoring for ADT side effects is crucial for patient management.
- Understanding and targeting reversible resistance mechanisms can improve outcomes.
- Strategic application of ADT and potentially bipolar androgen therapy can re-sensitize tumors.
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