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[Antihormonal therapy in prostate cancer : Side effects].

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Androgen deprivation therapy for prostate cancer can cause hidden side effects and resistance. Monitoring these issues and strategically using therapies like bipolar androgen therapy may restore treatment sensitivity.

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Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer treatment.
  • Common ADT drugs include abiraterone and enzalutamide.
  • Subtle side effects like metabolic, cardiovascular, and psychological changes are often overlooked.

Purpose of the Study:

  • To highlight the importance of monitoring occult side effects of ADT.
  • To discuss mechanisms of ADT resistance, including splice variants.
  • To explore strategies for overcoming ADT resistance.

Main Methods:

  • Review of current ADT practices and their associated challenges.
  • Analysis of molecular mechanisms underlying ADT resistance.
  • Discussion of potential therapeutic interventions.

Main Results:

  • ADT efficacy is often limited by primary and secondary resistance.
  • Molecular mechanisms, such as androgen receptor splice variants, are key to resistance.
  • These resistance mechanisms are often reversible.

Conclusions:

  • Active monitoring for ADT side effects is crucial for patient management.
  • Understanding and targeting reversible resistance mechanisms can improve outcomes.
  • Strategic application of ADT and potentially bipolar androgen therapy can re-sensitize tumors.