Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...

Bone Formation by Intramembranous Ossification

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...

Bone as Supporting Connective Tissue

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Subtyping youngsters with obesity: A theory-based cluster analysis.

Appetite·2021

Same author

Mesenchymal stem cell secretome decreases the inflammatory response in annulus fibrosus organ cultures.

European cells & materials·2021

Same author

The drive for thinness: Towards a mechanistic understanding of avoidance behaviors in a non-clinical population.

Behaviour research and therapy·2021

Same author

Obstetrical outcome after B-Lynch sutures and ligation of uterine arteries: A case report.

Case reports in women's health·2021

Same author

Animal models for studying metaphyseal bone fracture healing.

European cells & materials·2020

Same author

Degeneration alters the biomechanical properties and structural composition of lateral human menisci.

Osteoarthritis and cartilage·2020

Same journal

[Fast-track hip and knee joint arthroplasty].

Der Orthopade·2022

Same journal

[Outpatient care through cross-sector prehabilitation and rehabilitation concepts in outpatient hip and knee arthroplasty].

Der Orthopade·2022

Same journal

[Preoperative management in fast-track arthroplasty].

Der Orthopade·2022

Same journal

[Perioperative management in fast-track arthroplasty].

Der Orthopade·2022

Same journal

[Pain therapy and anaesthesiological procedures in fast-track arthroplasty].

Der Orthopade·2022

Same journal

[Discharge readiness versus discharge-Results of the PROMISE study].

Der Orthopade·2022

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 7, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Biodegradable bone cements.

L Claes¹, I Hoellen², A Ignatius¹

¹Abteilung Unfallchirurgische Forschung und Biomechanik, Universität Ulm, Germany.

|March 2, 2017

Summary

This summary is machine-generated.

Biodegradable calcium-phosphate bone cements offer temporary support for fractures and implants. Further clinical studies are needed to confirm their suitability for widespread medical use.

Keywords:

Key words Fracture healing • Bone cement • Degradation

More Related Videos

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Related Experiment Videos

Last Updated: Mar 7, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro

Published on: April 15, 2022

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

Area of Science:

Biomaterials Science
Orthopedic Surgery
Regenerative Medicine

Background:

Bone cements are crucial for treating fractures, bone defects, and improving implant fixation in osteoporotic patients.
Ideally, bone cements should degrade after fulfilling their supportive role, with biodegradable calcium-phosphate cements being a focus.
Recent advancements have led to calcium-phosphate bone cements with structures similar to bone apatite.

Purpose of the Study:

To review the development and characteristics of novel calcium-phosphate bone cements.
To assess the potential of these cements for clinical application in orthopedic procedures.

Main Methods:

Review of recent research on calcium-phosphate bone cement development.
Analysis of processing conditions, mechanical properties, and degradation characteristics.
Evaluation of existing literature regarding clinical applicability.

Main Results:

Various calcium-phosphate bone cements have been developed with apatite-like structures.
Significant variations exist in intraoperative processing, mechanical properties, and degradation behavior among different cements.
Long-term clinical data is currently lacking for these novel bone cements.

Conclusions:

Calcium-phosphate bone cements show promise as temporary, biodegradable materials for bone repair and augmentation.
The heterogeneity in properties necessitates further investigation to ensure safety and efficacy.
Future clinical studies are essential to determine if these cements meet all requirements for widespread orthopedic application.