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HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease

M K Viken^1,2,3, S T Flåm², T Skrivarhaug^3,4,5

¹Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway.

|March 2, 2017

Abstract

Background:

Type 1 diabetes (T1D) and celiac disease (CeD) are 2 distinct diseases, but there is an increased risk of developing CeD for T1D patients. Both diseases are associated with HLA-class II alleles, such as DQB1 *02:01 and DQB1 *03:02; however, their risk contribution vary between the diseases.

Materials And Methods:

We genotyped HLA-DRB1 and - DQB1 in 215 patients with coexisting T1D and CeD identified from a T1D cohort, and compared them to patients with T1D (N = 487) and CeD (N = 327), as well as healthy controls (N = 368).

Results:

The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01- DQB1 *02:01- DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).

Conclusion:

Overall, the patients with coexisting T1D and CeD had an HLA profile more similar to T1D patients than CeD patients.

Keywords:

HLA HLA-DQB1 HLA-DRB1 celiac disease type 1 diabetes

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