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Stimulation of the pituitary-adrenal axis with arginine vasopressin in patients with depression
W H Meller1, R C Kathol, R S Jaeckle
1Department of Psychiatry, University of Iowa Hospitals, Iowa City 52242.
Journal of Psychiatric Research
|January 1, 1987
Abstract:
The ACTH response to arginine vasopressin was the same in patients with depression while cortisol response was significantly greater in patients with depression when compared to the control population. These findings are consistent with the hypothesis that vasopressin corticotroph receptors are not downregulated in depression and that there is increased adrenal responsiveness in patients with depression to endogenous ACTH.