[MicroRNAs as potential noninvasive markers in the diagnosis of urological malignancies]
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MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
I R Gilyazova1, E A Klimentova1, V N Pavlov2
1Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences.
Abstract:
Small non-coding RNAs (microRNAs) are involved in almost all biological mechanisms of carcinogenesis. Due to their stability in biological fluids microRNAs may serve a perspective biomarker for diagnosis and prognosis of oncological diseases. The review is dedicated to the analysis of microRNAs, as potential diagnostic markers of urological malignancies. Recent advances in the knowledge of miRNAs origin in body fluids, their stability and application as a potentially new class of biomarkers in medicine are summarized and discussed in the article.
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