[A man's role in recurrent miscarriage in a spouse]

Area of Science:

• Reproductive Medicine
• Male Infertility
• Genetics

Background:

• Recurrent miscarriage affects couples, with increasing evidence highlighting male contributions.
• Elevated sperm DNA fragmentation is linked to adverse pregnancy outcomes and reduced assisted reproductive technology (ART) efficacy.
• Understanding male reproductive health is crucial for managing recurrent pregnancy loss.

Purpose of the Study:

• To review the male role in recurrent miscarriage and reproductive losses.
• To detail the impact of sperm DNA fragmentation on pregnancy and ART.
• To explore treatment strategies for male-related reproductive issues.

Main Methods:

• Literature review of published studies and original research.
• Analysis of etiological and pathogenetic factors of sperm DNA damage.
• Discussion of therapeutic interventions and surgical options.

Main Results:

• Elevated sperm DNA fragmentation negatively affects early pregnancy, increases miscarriage risk, and lowers ART success.
• Correction of lifestyle factors, varicocelectomy, and antioxidant therapy show positive effects.
• Male karyotype abnormalities, such as translocations, contribute to pregnancy loss.

Conclusions:

• Male factors are critical in recurrent miscarriage and reproductive failure.
• Interventions targeting male reproductive health, including urologic surgery and preimplantation genetic diagnosis, offer solutions.
• New treatment strategies focusing on correcting male disorders can improve outcomes for couples experiencing recurrent miscarriage.