Related Experiment Video
Updated: Aug 8, 2026
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
[Feasibility of using connective tissue prosthesis for autoplastic repair of urinary bladder wall defects (an
N V Tyumentseva1,2, B G Yushkov1,3,2, S Y Medvedeva1,3,2
1Institute of Immunology and Physiology, Ural Branch of RAS, Ekaterinburg.
Abstract:
Experiments on laboratory rats have shown the feasibility of autoplastic repair of urinary bladder wall defects using a connective-tissue capsule formed as the result of an inflammatory response to the presence of a foreign body. The formation of connective tissue prosthesis is characterized by developing fibrous connective tissue, ordering of collagen fibers, reducing the number of cells per unit area with a predominance of more mature cells - fibroblasts. With increasing time of observation, connective tissue prostheses were found to acquire a morphological structure similar to that of the urinary bladder wall. By month 12, the mucosa, the longitudinal and circular muscle layers were formed. The proposed method of partial autoplastic repair of urinary bladder wall is promising, has good long-term results, but requires further experimental studies.
