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Twist of fate for skeletal muscle mesenchymal cells
Natalya A Goloviznina1, Michael Kyba1
1Lillehei Heart Institute, and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Nature Cell Biology
|March 2, 2017
Abstract:
Skeletal muscles are composed of different types of fibres. Can these be thought of as distinct lineages with specific lineage-restricted progenitors? A provocative study now proposes that mesenchymal cells expressing the transcription factor Twist2 act as myogenic progenitors with selective type IIb fibre-differentiation potential.
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