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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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Stimuli-Responsive DNA-Based Hydrogels: From Basic Principles to Applications.

Jason S Kahn1, Yuwei Hu1, Itamar Willner1

  • 1Institute of Chemistry, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.

Accounts of Chemical Research
|March 2, 2017
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Summary
This summary is machine-generated.

This study presents novel stimuli-responsive DNA-based hydrogels that can transition between solution, hydrogel, and solid states. These smart materials offer tunable properties for applications in drug delivery, sensing, and information storage.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Nucleic acids encode information and can form switchable structures triggered by external stimuli.
  • Stimuli-responsive hydrogels are of interest for drug delivery, sensing, and smart materials.
  • Integrating DNA structures into hydrogels offers tunable physical, structural, and chemical properties.

Purpose of the Study:

  • To develop stimuli-responsive DNA-based hydrogels with switchable properties.
  • To demonstrate reversible transitions between solution, hydrogel, and solid states.
  • To explore applications in drug delivery, catalysis, and information storage.

Main Methods:

  • Integration of stimuli-responsive DNA structures into acrylamide polymer chains.
  • Utilizing external triggers like metal ions, pH, and G-quadruplexes for hydrogel transitions.
  • Combining DNA bridges with thermosensitive poly(N-isopropylacrylamide) (pNIPAM) for reversible state changes.
  • Developing surface-confined hydrogel films and microcapsules via hybridization chain reaction (HCR).

Main Results:

  • Demonstrated reversible hydrogel-to-solution transitions triggered by external stimuli.
  • Achieved reversible solution ↔ hydrogel ↔ solid transitions using DNA bridges and pNIPAM.
  • Created shape-memory hydrogels with switchable transitions between shaped and shapeless states.
  • Fabricated hydrogel films with switchable stiffness and signal-triggered catalytic functions.
  • Prepared stimuli-responsive microcapsules for controlled drug release applications.

Conclusions:

  • Stimuli-responsive DNA-based hydrogels offer versatile platforms for advanced material applications.
  • These hydrogels can be engineered for controlled drug delivery, catalysis, and information storage.
  • The developed materials exhibit tunable properties and switchable functions based on external signals.