Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies
Katri V Typpo1, Hector R Wong, Stacey D Finley
11Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.
Insights
New biomarkers and tests show promise for assessing and monitoring multiple organ dysfunction syndrome (MODS) in children. Further validation could improve understanding and treatment of this critical condition.
Area of Science:
- Pediatric Critical Care Medicine
- Biomarker Discovery
- Diagnostic Technologies
Background:
- Multiple organ dysfunction syndrome (MODS) is a significant cause of mortality in critically ill children.
- Current methods for assessing MODS severity and progression have limitations.
- Early and accurate assessment is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To review emerging biomarkers and diagnostic tests for pediatric MODS.
- To discuss technologies presented at the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop.
- To evaluate the potential of these innovations in clinical practice.
Main Methods:
- Literature review and synthesis of research data.
- Expert opinion and discussion from a dedicated workshop.
- Analysis of presentations on novel technologies for critical illness.
Main Results:
- Numerous innovative tools and techniques were identified for MODS assessment.
- These technologies offer potential for improved monitoring of disease severity and progression.
- Presentations highlighted advancements in understanding pediatric critical illness.
Conclusions:
- Emerging technologies hold significant promise for pediatric MODS management.
- Establishing the reliability and clinical utility of these tools is essential.
- Successful implementation could enhance understanding, monitoring, and treatment of pediatric MODS.
Objective:
To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015).
Data Sources:
Literature review, research data, and expert opinion.
Study Selection:
Not applicable.
Data Extraction:
Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature.
Data Synthesis:
Summary of presentations and discussion supported and supplemented by relevant literature.
Conclusions:
There are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.
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