Association factor analysis between osteoporosis with cerebral artery disease: The STROBE study

Area of Science:

• Neurology
• Orthopedics
• Radiology

Background:

• Osteoporosis and cerebral artery disease are significant health concerns, particularly in aging populations.
• Understanding the clinical associations between these conditions is crucial for comprehensive patient management.

Purpose of the Study:

• To investigate the clinical factors associated with osteoporosis and cerebral artery disease in the Korean population.
• To identify specific fracture types and clinical characteristics linked to cerebrovascular conditions.

Main Methods:

• A cross-sectional study involving 219 Korean adults undergoing cerebral computed tomography angiography.
• Cerebral artery disease diagnosed by vessel narrowing or calcification; osteoporotic fractures assessed via medical records and imaging.
• Statistical analyses included chi-square tests, t-tests, and univariate/multivariate logistic regression.

Main Results:

• 142 out of 219 patients had cerebral artery disease; 29 patients had vertebral fractures.
• Osteoporotic hip fracture showed a significant association with extracranial cerebral artery disease.
• Female patients with osteoporotic hip fractures were linked to total calcified cerebral artery disease.

Conclusions:

• Osteoporotic hip fracture is a significant clinical factor associated with extracranial cerebral artery disease.
• Age, hypertension, smoking history, and anti-osteoporosis drug use are also associated with cerebral artery disease.
• These findings highlight the interconnectedness of skeletal and vascular health.